Marieke Emonts – le Clercq
Consultant Paediatric Infectious Diseases and Immunology
Honorary Senior Clinical Lecturer
Great North Children’s Hospital, Newcastle upon Tyne Hospitals Foundation Trust
Institute of Cellular Medicine, Newcastle University
Newcastle upon Tyne, UK
As consultant Paediatric Infectious Diseases & Immunology and Honorary Senior Clinical Lecturer I have a sound background in clinic and research from the start. I studied Medicine and Biomedical Sciences in Leiden, the Netherlands, after which I combined my Paediatric training with a PhD post in the Paediatric Infectious Diseases Laboratory at Erasmus MC, Rotterdam, The Netherlands.
I completed my PhD on immunogenetics of infectious and inflammatory diseases in 2008. Initially focussing on meningococcal disease I broadened my horizon to include other bacterial infections. My PhD formed the start of wonderful collaborations resulting in participation in two large European funded consortia, EUCLIDS and PERFORM.
The overarching theme in activities is the promotion of therapeutic possibilities for childhood infections, particularly in an era of increasing antimicrobial resistance. This requires focus of the research on:
1. Early recognition of the type of infection: bacterial vs viral, and type of bacterial infection. This can minimise the unnecessary use of antimicrobials in patients presenting with fever at an A&E, and thus prevent antimicrobial resistance.
2. Identification of alternative therapeutic targets, particularly in recurrent infective conditions to circumvent antimicrobial resistance. Innate immune factors could be these targets and elucidating their role in infection will aid in identifying which ones could also be targeted for prevention and/or treatment.
To this end we recently completed a.o. the evaluation of two large case series on VP shunt infections and suppurative intracranial infections respectively, in our centre. This is a large tertiary referral centre for Paediatrics in the North East of England, and home to a complete spectrum of Paediatrics, from community paediatrics, to intensive care, and including surgery, oncology and bone marrow transplant.
We welcome (inter)national students and (trainee) paediatricians to come and work in our department.